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Stereoisomers of Quinine

Quinine is well-known antimalarial drug from the bark of the cinchona tree. In principle, how many stereoisomers of quinine are possible?
[http://datquestionoftheday.com/wp-content/uploads/2013/03/Q1.png]

A. 2.

B. 4.

C. 8.

D. 16.

E. 32.

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