Also: What would another Trump presidency mean for health care?

April 23, 2024

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By Theresa Gaffney

Morning Rounds Writer and Podcast Producer

 

Morning, everyone! If you read Helen Branswell's story from Sunday about the bird flu genetic sequences released by USDA, you may be interested in how the story's been updated. Scientists were quickly frustrated after realizing key information had been left out of the files

Also: Are you tired of my reminders to take the newsletter survey? Our newsletter editor is on vacation until next week and I know it would make her so happy to return to a ton of responses. 

 

POLICY

What would another Trump presidency mean for U.S. health care? 

GettyImages-2147787077Getty Images

Seven months before the presidential election, Donald Trump’s health care priorities remain fuzzy at best. He has seesawed on federal abortion bans, the prospect of repealing the Affordable Care Act, and ways to lower drug costs, struggling to find a message that will resonate with voters who have largely backed President Biden’s approach on these issues. But it’s clear that wherever he lands, a second Trump administration would put its own stamp on a host of critical issues.

STAT’s Sarah Owermohle spoke to six former officials and people close to Trump’s orbit who said that the Trump campaign is still in the early stages of creating his health policy agenda. Read more to learn what these insiders said about the former president’s evolving message.


GENE EDITING

CRISPR base editing used to treat liver disease in fetal monkeys

The ambitious idea of using CRISPR to cure genetic diseases before birth is one step closer to reality. Scientists reported yesterday that they used a form of the technology known as “base editing” to alter the DNA of laboratory monkeys in the womb, reducing the levels of a toxic protein that causes a fatal liver disease before the animals had even been born.

The researchers used an ultrasound-guided needle to inject the CRISPR components into the umbilical vein, which connects the fetus to the sedated mother. Fetal surgeons currently use a similar procedure to perform blood transfusions on fetal patients that have been diagnosed with certain blood disorders. “This opens up a lot of possibilities,” said Kiran Musunuru, a co-leader of the study. Read more from STAT’s Megan Molteni on the groundbreaking work and what researchers hope to do next


virtual care

Telehealth startups turn to complex chronic disease

For someone with a complex chronic condition, it can take a decade to get a proper diagnosis, as providers try to piece together multiple symptoms affecting different parts of the body. All the while, patients have to explain themselves over and over again as they try to manage their symptoms. That frustration looks like opportunity to a growing number of telehealth companies built around underserved chronic diseases, STAT’s Isa Cueto reports.

There’s room to make a difference, and “there’s a lot of monetary reasons as well why investing in underserved chronic condition markets is sort of appealing,” said Surbhi Sarna, a partner at the venture capital firm Y Combinator. But it won’t be simple. Read more from Isa on the companies that have cropped up, and how they’re approaching this complicated form of care.



first opinion

How to cope when your professional predecessors worked on CIA mind control projects

Psychedelic-CIAChristine Kao for STAT 

Casimir Klim, a fourth-year psychiatry resident at the Mayo Clinic, is fascinated by the troubled history of his chosen profession. Still, he found it jarring to learn that during the 1950s and 1960s, psychiatrists at America’s top academic institutions supported two CIA projects that aimed to identify methods of controlling thought and behavior. This work often involved experimentation on vulnerable people, such as those who were incarcerated or in psychiatric wards. Physicians at Klim’s own institution had conducted extensive research on deep brain stimulation, hypnosis, and psychedelic drugs — all of which the CIA attempted to use for their mind control programs.

“I found the matter-of-fact manner in which these physicians expounded on how medical science could be repurposed for coercion and domination jarring and nauseating to read,” Klim writes in a First Opinion essay on his research. Read more on what he learned about his profession and himself after looking into this partnership.


research

Female physicians deliver better results, especially for female patients

A large new study published yesterday in Annals of Internal Medicine found that in a cohort of close to 800,000 Medicare patients, those who were treated by a female physician had lower mortality and readmission rates. While previous research has shown that patients see better outcomes with female physicians, here the improvement was especially significant for female patients, STAT’s Nalis Merelli tells us. 

“Generally speaking, miscommunication, misunderstanding, and bias are more likely to occur when those in the majority become advocates for the minority,” Atsushi Miyawaki, the study’s corresponding author, said in an email to STAT — like when a male physician treats a female patient. Male patients had similar mortality and readmission rates regardless of their physician’s gender, something that Miyawaki said should be subject to further investigation.


heart disease

Afib more common in young people than previously thought, per study

Atrial fibrillation, the most common type of abnormal heart beat, is on the rise among people under age 65, according to a study published yesterday in Circulation: Arrhythmia and Electrophysiology. The study included more than 67,000 people with Afib treated at the UPMC Heart and Vascular Institute between 2010 and 2019. Nearly a quarter of those patients were under 65 — a rate much higher than the typically cited prevalence of about 2%, the authors wrote. 

The younger adults with Afib were more likely to be hospitalized for heart failure, stroke, or heart attack, and had significantly higher mortality rates compared to people of similar age and gender. They also had a high number of cardiovascular risk factors including smoking, high BMI, diabetes, heart failure, a previous stroke, and more, which can contribute to further damaging the heart over time, researchers noted.


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What we're reading

  • Oncologists’ meetings with drug reps don't help cancer patients live longer, NPR
  • Rural jails turn to community health workers to help the newly released succeed, KFF Health News
  • Biden administration finalizes abortion privacy protections, STAT
  • A dentist found a jawbone in a floor tile, The Atlantic
  • ‘Devalued, disempowered, and unseen’: Mass General Brigham doctors react to latest merger step, STAT

Thanks for reading! More tomorrow,

 

 


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